Manual práctico de Trombosis y Hemostasia de la SETH

I . E L L A B O R A T O R I O D E H E M O ST A S I A — 5 8 — CONCLUSIONES La evaluación de un paciente con hemorragia requiere una cuidadosa historia clínica y examen físico. Los índices de he- morragia son de utilidad por su elevado valor predictivo negativo. El diagnóstico de laboratorio debe adecuarse a la presentación clínica y la probabilidad de detectar un tras- torno hemorrágico subyacente. La combinación apropiada de pruebas sencillas de hemostasia primaria y secundaria permitirá categorizar el cuadro clínico y, con ello, estable- cer la profilaxis y tratamiento más adecuado del trastorno hemorrágico. BIBLIOGRAFÍA 1. Coller BS, Schneiderman PI. Clinical evaluation of hemorrhagic di- sorders: the bleeding history and differential diagnosis of purpura. In: Hematology. Basic principles and practice. Hoffmann M, et al. (eds). Philadelphia: Churchil Livignstone; 2009; p. 1851-76. 2. Rodeghiero F, Castaman G, Tosetto A, Batlle J, Baudo F, Cappe- lletti A, et al.The discriminant power of bleeding history for the diagnosis of type 1 vonWillebrand disease: an international, mul- ticenter study. J Thromb Haemost 2005;3:2619-26. 3. James AH. More than menorrhagia: a review of the obstetric and gynaecological manifestations of bleeding disorders. Haemophilia 2005;11;295-307. 4. Rodeghiero F, Tosetto A, Abshire T, Arnold DM, Coller B, Ja- mes P, et al; ISTH/SSC joint VWF and Perinatal/Pediatric He- mostasis Subcommittees Working Group. ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders. J Tromb Hemost 2010;8:2063-5. 5. Tosetto A, Castaman G, Plug I, Rodeghiero F, Eikenboom J. Pros- pective evaluation of the clinical utility of quantitative bleeding severity assessment in patients referred for hemostatic evalua- tion. J Thromb Haemost 2011;9:1143-8. 6. Sucker C.The Heyde síndrome: proposal for a unifying concept explaining the association of aortic valve stenosis, gastrointestinal angiodysplasia and bleeding. Int J Cardiol 2007;115:77-8. 7. Páramo JA, García Frade LJ. Diagnóstico de los trastornos de la hemostasia. Pregrado Hematología. 4.ª ed. Madrid: Luzán; 2017. p. 579-90. 8. Ma A, Mazepa M. Evaluation of the bleeding patient. In: Practical Hemostasis andThrombosis. 3 rd ed. Key NS, Makris M, Lillicrap D, editores. New Jersey:Wiley Blackwell; 2017. p. 63-78. 9. Nurden P, Nurden AT. Congenital disorders associated with pla- telet dysfunction.Thromb Haemost 2008:99:253-63. 10. Gresele P, Falcinelli E, Bury L. Inherited platelet function disor- ders. Diagnostic approach and management. Hamostaseologie 2016;36:265-78. 11. O´Brien SH, Ritchey AK, Ragni MV. Combined clotting factor deficiencies: experience at a single hemophilia treatment center. Haemofilia 2007:13:26-9. 12. Zhang B, Ginsburg D. Familial multiple coagulation factor defi- ciencies: new biological insight from genetic bleeding disorders. J Thromb Haemost 2004;2:1564-72. 13. Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leis- singer CA, et al. Acquired hemophilia A: Updated review of evi- dence and treatment guidance. Am J Hematol 2017;92:695-705.