XXXIII Congreso Nacional de la Sociedad Española de Trombosis y Hemostasia

Ponencias 81 Tabla III. Variantes genéticas potencialmente asociadas con el riesgo de trombosis venosa Gen Proteína Mutación/Variante genética Riesgo F2 Factor II; Protrombina rs3136516 (A19911G) 1,43 (para G/G) F3 Factor III; Factor tisular (TF) 1208indel 1,06 F5 Factor V rs1800595 1,18 F8 Factor VIII rs1800291; rs114209171-T 1,13/1,153 F9 Factor IX rs6048; rs4149755 1,08/1,50 F10 Factor X rs69333 0,80 F11 Factor XI rs4444878; rs3822057; rs4253399-C 0,81/1,06/1,28 F13B Cadena B Factor XIII rs6003 1,09 FGA Fibrinógeno α rs6050; rs2070006 1,40/1,25 FGB Fibrinógeno β rs1800788 1,30 FGG Fibrinógeno γ rs7654093 1,216 PROC Proteína C rs5937; rs2069915; rs1799809 1,37/0,78/1,17 PROCR Receptor endotelial de la PC (EPCR) rs34234989; rs9574 (G4678C); rs2069951 0,885/0,50/1,30 STAB2 Stabilin-2 rs4981021 1,29 TC2N Tandem C2 domains nuclear protein rs1884841 1,22 ABO Grupo sanguíneo ABO rs2519093 † ; rs529565 1,68/0,723 LY86 Lymphocyte antigen 86 rs1073897*-A; rs9328375*-A 0,68/0,71 KLKB1 Plasma kallikrein rs3087505-A 0,63 SCUBE1 Signal peptide, CUB and EGF-like domain-containing protein 1 rs5759224-G 1,43 GFRA1 GDNF family receptor alpha-1 rs10749203 ‡ -A; rs881726 ‡ -G; rs10787637 ‡ -G 0,72/0,72/0,74 COX7A2L/ KCNG3 Cytochrome c oxidase subunit 7A2 like/Potassium voltage- gated channel subfamily G member 3 rs72798544 0,733 TSPAN15 Tetraspanin-15 rs17490626 1,165 SLC44A2 Choline transporter-like protein 2 rs9797861 1,145 TMEM170B/ ADTRP transmembrane protein 170B/androgen dependent TFPI regulating protein rs113092656 0,728 EPHA3 Ephrin type-A receptor 3 rs60942712 1,211 ANX5 Annexin A5 Haplotipo M2 # 1,90 APOA4 Apolipoprotein A4 Gln360His 0,34 BAI3 Brain-specific angiogenesis inhibitor 3 rs9363864 0,58 CYP4V2 Cytochrome P450 4V2 rs13146272 1,20 SELE E-selectina rs5355 (Leu554Phe) 0,39 IL1RN Interleukin-1 receptor antagonist rs2232354 3,90 (Continúa en la página siguiente)