XXXIII Congreso Nacional de la Sociedad Española de Trombosis y Hemostasia

XXXIII Congreso Nacional de la Sociedad Española de Trombosis y Hemostasia 52 platelets. Transfusion 2013;53:3088-99. 15. Da Luz LT, Nascimento B, Shankarakutty AK, Rizoli S, Adhikari NK, Effect of thromboelastography (TEG ® ) and rotational thromboelas- tometry (ROTEM ® ) on diagnosis of coagulopathy, transfusion guid- ance and mortality in trauma: descriptive systematic review. Crit Care 2014;18:518. DOI: 10.1186/s13054-014-0518-9. 16. Hunt H, Stanworth S, Curry N, Wooley T, Cooper C, Ukoumunne O, et al. Thromboelastography (TEG ® ) and rotational thromboelastometry (ROTEM ® ) for trauma-induced coagulopathy in adult trauma patients with bleeding. Cochrane Database Syst Rev 2015; CD010438. DOI: 10.1002/14651858. CD010438. 17. WikkelsøA,Wetterslev J, MøllerAM,AfshariA. Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treat- ment versus usual care in adults or children with bleeding. Cochrane Database of Syst Rev 2016; CD007871. DOI: 10.1002/14651858. CD007871 18. Simmons JW, Pittet JF, Pierce B. Trauma-induced coagulopathy. Curr Anesthesiol Rep 2014;4:189-99. 19. Fernández-Hinojosa E, Murillo-Cabezas F, Puppo-MorenoA, Leal-No- val SR.Alternativas terapéuticas de la hemorragia masiva. Med Intensiva 2012;36: 496-503. 20. Wong H, Curry N, Stanworth SJ. Blood products and procoagulants in traumatic bleeding: use and evidence. Curr Opin Crit Care 2016; 22:598-606. 21. Johansson PI, Stensballe J. Hemostatic resuscitation for massive bleed- ing: the paradigm of plasma and platelets ─ a review of the current liter- ature. Transfusion 2010;50:701-10. 22. Stensballe J, Ostrowski SR, Johansson PI. Haemostatic resuscitation in trauma: the next generation. Curr Opin Crit Care 2016;22:591-7. 23. Mercer SJ, Tarmey NT, Woolley T, Wood P, Mahoney PF. Haemor- rhage and coagulopathy in the Defence Medical Services. Anaesthesia 2013;68(1):49-60. 24. Spinella PC, Pidcoke HF, Strandenes G, Hervig T, Fisher A, Jenkins D, et al. Whole blood for hemostatic resuscitation of major bleeding. Transfusion 2016; 56(2):S190-S202. 25. Callcut RA, Cotton BA, Muskat P, Fox EE,Wade CE, Holcomb JB, et al; PROMMTT StudyGroup. Definingwhen to initiatemassive transfusion: a validation study of individual massive transfusion triggers in PROM- MTT patients. J TraumaAcute Care Surg 2013;74:59-68. 26. Pohlman TH, Walsh M, Aversa J, Hutchinson EM, Olsen KP, Law- rence-ReedR. Damage control resuscitation. BloodRev 2015;29:251-62. 27. Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Per- kins JG, et al. Trauma Outcomes Group. Increased platelet: RBC ratios are associatedwith improved survival after massive transfusion. J Trauma 2011;71(2-3):S318-S328. 28. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al; PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs. 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomizzed clinical trial. JAMA2015;313:471-82. 29. Mesar T, Larentzakis A, Disk W, ChangY, Velamos G, Yeh DD. Asso- ciation between ratio of fresh frozen plasma to red blood cells during massive transfusion and survival among patients without traumatic inju- ry. JAMA Surg. 2017; DOI: 10.1001/jamasurg.2017.0098 ; Published online March 8, 2017. 30. Johansson PI, Stensballe J, Oliveri R, Wade CE, Ostrowski SR, Hol- comb JB. How I treat patients with massive hemorrhage. Blood 2014;124:3052-8. 31. Comisión de Transfusión y Hemoterapia. Protocolo de Transfusión Masiva del Hospital UniversitarioVirgen del Rocío de Sevilla; segunda versión. Sevilla; octubre 2014. Disponible en: www.huvr.es 32. González E, Moore EE, Moore HB, Chapman MP, Chin TL, Gha- sabyan A, et al. Goal-directed hemostatic resuscitation of trauma-in- duced coagulopathy: a pragmatic randomized clinical trial compar- ing a viscoelastic assay to conventional coagulation assays. Ann Surg 2016;263:1051-9. 33. Hunt BJ. The current place of tranexamic acid in the management of bleeding. Anaesthesia 2015;70(1):50-3. 34. Ker K, Roberts I. Exploring redundant research into the effect of tranexamic acid on surgical bleeding: further analysis of a systematic review of randomised controlled trials. BMJ Open 2015;5:e009460. 35. CRASH-2 Trial collaborators. Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood trans- fusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo controlled trial. Lancet 2010;376:23-32. 36. WafaisadeA, Lefering R, Bouillon B, et al. Prehospital administration of tranexamic acid in trauma patients. Crit Care 2016;20:143. 37. Napolitano LM. Prehospital tranexamic acid: what is the current evi- dence? Trauma Surg Acute Care Open 2017;2:1-7. DOI: 10.1136/tsa- co-2016-000056. 38. DewanY, Komolafe EO, Mejía-Mantilla JH, Perel P, Roberts I, Shakur H, on behalf of CRASH-3 Collaborators. CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials 2012;13:87. DOI: 10.1186/1745-6215-13-87. 39. WOMAN Trial Collaborators. Effect of early tranexamic acid admin- istration on mortality, hysterectomy, and other morbidities in women with post-partumhaemorrhageWOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017;389:2105-16. 40. Glen J, Constanti M, Brohi K. Assessment and initial management of major trauma: summary of NICE guidance. BMJ 2016;353:i3051. 41. Hagemo JS, Stanworth S, Juffermans NP, Brohi K, CohenM, Lohansson PI, et al. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Crit Care 2014;18:R52. 42. Innerhofer P, Fries D, Mittermayr M, Innerhofer N, von Langen D, Hell T, et al. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a sin- gle-centre, parallel-group, open-label, randomised trial. Lancet Haematol 2017 ; PublishedOnline April 27, 2017 http://dx.doi.org/10.1016/ S2352- 3026(17)30077-7. 43. Leal-Noval SR, Casado M, Arellano-OrdenV, Dusseck R, Bautista-Pa- loma J, Muñoz M, et al. Administration of fibrinogen concentrate for refractory bleeding in massively transfused, non-trauma patients with coagulopathy: a retrospective study with comparator group. BMCAnes- thesiology 2014,14:109. DOI: 10.1186/1471-2253-14-109. 44. Wikkelsø A, Lunde J, Johansen M, Stensballe J, Wetterslev J, Møller AM, Afshari A. Fibrinogen concentrate in bleeding patients. Cochrane Database of Syst Rev 2013; CD008864. DOI: 10.1002/14651858. CD008864.pub2. 45. Wikkelsø A, Edwards HM, Afshari A, Stensballe J, Langhoff-Ross J, Albrechtsen C, et al. Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized contrlled trial. Br J Anaesth 2015;114:623-33. 46. AEMPS. Prothomplex ® : ficha técnica. 47. AEMPS. Beriplex ® : ficha técnica. 48. Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G. Oral anticoagulant therapy: antithrombotic therapy and prevention of trombosis, 9th Ed: ACCP evidence-based clinical practice guidelines. CHEST 2012;141(2):E44s–E88s. 49. Leal-Noval SR, López-Irizo R, Bautista-Paloma J, Casado M, Arella- no-OrdenV, Leal-RomeroM, et al. Efficacy of the prothrombin complex concentrate in patients requiring urgent reversal of vitamin K antagonists or presenting with uncontrolled bleeding: a retrospective, single center study. Blood Coag Fibrinolysis 2013,24:862-8. 50. AgenoW, Büller H, FalangaA, Persson E, HillarpA. Managing reversal of direct oral anticoagulants in emergency situations. Anticoagulation EducationTask ForceWhite Paper. ThrombHaemost 2016;116:1003-10. 51. AEMPS. FEIBA ® : ficha técnica. 52. Lindahl TL, Wallstedt M, Gustafsson KM, et al. More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin complex concentrate